Sunday, November 22, 2015


For increasing reactivity of carboxylic acid derivatives in nucleophilic acyl substitution, the order of reactivity goes nitriles<amides<esters and acids<anhydrides< acid chlorides, right? (Almost. Remove the acid from the row, because it forms a salt instead of undergoing acyl substitution. - GS). If so, is that the same reactivity for hydrolysis? (Yes. - GS). Thank you!

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